Role of Radiation in Metachronous Multicentric Giant Cell Tumor of Bone: A Case Report

Nana Supriana; David Andi Wijaya

doi:10.32532/jori.v12i2.141

Role of Radiation in Metachronous Multicentric Giant Cell Tumor of Bone: A Case Report

Nana Supriana, David Andi Wijaya

Sari

Introduction: Giant cell tumor of the bone (GCTB) is a rare benign locally aggressive tumor. Surgical resection whenever feasible is treatment of choice for GCTB.

Case Presentation: In this report the author will review a case of well locally controlled postoperative GCTB on left ilium bone after adjuvant radiation was delivered, with metachronous lesion on right calcaneus and distal tibia which appeared 9 years later.

Conclusions: Radiation either in adjuvant setting or definitive in unresectable lesion could bring adequate local control.

Kata Kunci

Giant cell tumor of bone, Radiation, Metachronous, Multicentric

Teks Lengkap:

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Referensi

Dorfman H, Czerniak B. Dorfman and Czerniak’s bone tumors. 2nd ed. 1998.

Forsyth R, Hogendoorn P, Cleven A, Bovee J. Giant cell tumour of bone.

Gunasegaran K, Irawan MNSB, Yantiasetiasti A. Epidemiology of giant cell tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013. Althea Med J. 2016;3(2):244–7.

Tandra VS, Kotha KMR, Satyanarayana MGV, Vadlamani KV, Yerravalli V. Synchronous multicentric giant cell tumour of distal radius and sacrum with pulmonary metastases. Case Rep Oncol Med. 2015;2015:1–5.

Hoch B, Inwards C, Sundaram M, Rosenberg A. Multicentric giant cell tumor of bone. J Bone Jt Surg. 2006;1998–2009.

Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013 Dec;45(12):1479–82.

Amary F, Berisha F, Ye H, Gupta M, Gutteridge A, Baumhoer D, et al. H3F3A (Histone 3.3) G34W immunohistochemistry. Am J Surg Pathol. 2017 Aug;41(8):1059–68.

Lau CPY, Wong KC, Huang L, Li G, Tsui SKW, Kumta SM. A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. Connect Tissue Res. 2015 Nov;56(6):493–503.

Chang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, et al. Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. Clin Orthop Relat Res. 2004 Sep;426:103–9.

Lau CPY, Huang L, Wong KC, Kumta SM. Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone. Connect Tissue Res. 2013 Nov;54(6):439–49.

Yang T, Zheng X-F, Li M, Lin X, Yin Q-S. Stimulation of osteogenic differentiation in stromal cells of giant cell tumour of bone by zoledronic acid. Asian Pacific J Cancer Prev. 2013 Sep;14(9):5379–83.

Poudel RR, Verma V, Tiwari A. Multicentric giant cell tumor ( GCT ) of bone treated with denosumab alone : A report of two cases. J Clin Orthop Trauma. 2019;10(6):1050–3.

Shi W, Indelicato DJ, Reith J, Smith KB, Morris CG, Scarborough MT, et al. Radiotherapy in the management of giant cell tumor of bone. Am J Clin Oncol. 2013 Oct;36(5):505–8.

Miszczyk L, Wydmański J, Spindel J. Efficacy of radiotherapy for giant cell tumor of bone: given either postoperatively or as sole treatment. Int J Radiat Oncol. 2001 Apr;49(5):1239–42.

Caudell JJ, Ballo MT, Zagars GK, Lewis VO, Weber KL, Lin PP, et al. Radiotherapy in the management of giant cell tumor of bone. Int J Radiat Oncol. 2003 Sep;57(1):158–65.

DOI: https://doi.org/10.32532/jori.v12i2.141 <