The effect of bone radiation on hematopoiesis: A literature review

Rendhy Tito Apreza; Soehartati A. Gondhowiardjo

doi:10.32532/jori.v12i2.135

The effect of bone radiation on hematopoiesis: A literature review

Rendhy Tito Apreza, Soehartati A. Gondhowiardjo

Sari

Over time, external radiation techniques have continued to evolve so that they can be used to
treat bone malignancies for curative, postoperative adjunct, and metastases purposes. However,
in the bone, there is the bone marrow that is sensitive to radiation. Even sublethal doses can
cause bone marrow microenvironment deficits, including a decrease in hematopoietic cells.
There is a complex relationship between radiotherapy (RT) and the hematopoietic system.
Acute radiation injury usually manifests as cytopenia: anemia, neutropenia, and
thrombocytopenia. Several potential mechanisms regarding the effects of radiotherapy on bone
marrow, including direct damage to the hematopoietic stem cells (HSC), lead to decreased
number and function. This literature review will discuss hematopoiesis, the effect of bone
radiation on hematopoiesis, and its mechanisms.

Kata Kunci

Bone, Hematopoiesis, Radiotherapy

Teks Lengkap:

PDF (English)

Referensi

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DOI: https://doi.org/10.32532/jori.v12i2.135 <