External Beam Radiotherapy in limited setting: Optimizing Cobalt-60 for forward planning field-in-field intensity modulation technique in nasopharyngeal cancer Irradiation

Elia Aditya Bani Kuncoro; Piryadi Piryadi; William Alfred Lapian Pandeirot; Yunarti Yunarti; Anita Zakiyah; Galih Puspa Sekarsari

doi:10.32532/jori.v12i1.119

External Beam Radiotherapy in limited setting: Optimizing Cobalt-60 for forward planning field-in-field intensity modulation technique in nasopharyngeal cancer Irradiation

Elia Aditya Bani Kuncoro, Piryadi Piryadi, William Alfred Lapian Pandeirot, Yunarti Yunarti, Anita Zakiyah, Galih Puspa Sekarsari

Sari

Cobalt-60 adalah salah satu modalitas teleterapi yang paling tua, namun masih digunakan di beberapa negara berkembang. Modifikasi bisa dilakukan untuk mengoptimalkan kemampuan pesawat Cobalt-60 dalam pengobatan kanker nasofaring.

Penulis mengembangkan teknik field-in-field pada pesawat Cobalt-60. Beberapa penyulit / keterbatasan berusaha disesuaikan dengan cara mengubah pemberian dosis, peletakan isosenter, collimator, dan blok. Teknik penyinaran ini menggunakan 12-15 lapangan dalam menggunakan 7-9 blok, yang diletakkan dalam 3-5 trays.

Teknik ini mampu mencapai kriteria yang ditetapkan untuk planning approval. Sembilan pasien yang telah menjalani terapi mengalami efek samping akut yang dapat diterima, dengan tingkat complete response 71%.

Teknik Forward planning field-in-field bisa digunakan untuk membantu mengatasi beberapa keterbatasan pesawat Cobalt-60 dan menunjukkan hasil yang baik.

Kata Kunci

Cobalt-60, field-in-field, modulasi intensitas, kanker nasofaring

Teks Lengkap:

PDF (English)

Referensi

Fox, C., Romeijn, H. E., Lynch, B., Men, C., Aleman, D. M., & Dempsey, J. F. (2008). Comparative analysis of60Co intensity-modulated radiation therapy. Physics in Medicine and Biology, 53(12), 3175-3188. https://doi.org/10.1088/0031-9155/53/12/007

Page, B. R., Hudson, A. D., Brown, D. W., Shulman, A. C., Abdel-Wahab, M., Fisher, B. J., & Patel, S. (2014). Cobalt, linac, or other: What is the best solution for radiation therapy in developing countries? International Journal of Radiation Oncology*Biology*Physics, 89(3), 476-480. https://doi.org/10.1016/j.ijrobp.2013.12.022

Lee, N., Harris, J., Garden, A. S., Straube, W., Glisson, B., Xia, P., Bosch, W., Morrison, W. H., Quivey, J., Thorstad, W., Jones, C., & Ang, K. K. (2009). Intensity-modulated radiation therapy with or without chemotherapy for Nasopharyngeal carcinoma: Radiation therapy oncology group phase II trial 0225. Journal of Clinical Oncology, 27(22), 3684-3690. https://doi.org/10.1200/jco.2008.19.9109.

Lee, A. W., Ng, W. T., Pan, J. J., Poh, S. S., Ahn, Y. C., AlHussain, H., Corry, J., Grau, C., Grégoire, V., Harrington, K. J., Hu, C. S., Kwong, D. L., Langendijk, J. A., Le, Q. T., Lee, N. Y., Lin, J. C., Lu, T. X., Mendenhall, W. M., O'Sullivan, B., … Wee, J. T. (2018). International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma. Radiotherapy and Oncology, 126(1), 25-36. https://doi.org/10.1016/j.radonc.2017.10.03

Podgoršak, E. B. (2005). Radiation oncology physics: A handbook for teachers and students. IAEA. https://www-pub.iaea.org/mtcd/publications/pdf/pub1196_web.pdf

Sharma, S. (2014). Challenges of small photon field dosimetry are still challenging. Journal of Medical Physics, 39(3), 131. https://doi.org/10.4103/0971-6203.138998

Hu, W., Ding, W., Yang, H., Shao, M., Wang, B., Wang, J., Wu, S., Wu, S., Jin, L., & Ma, C. C. (2009). Weekly paclitaxel with concurrent radiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma. Radiotherapy and Oncology, 93(3), 488-491. https://doi.org/10.1016/j.radonc.2009.06.030

Bossi, P., Parolini, D., Bergamini, C., Locati, L. D., Orlandi, E., & Franceschini, M. (2009, May 20). TPF induction chemotherapy (CT) followed by concomitant cisplatin/radiotherapy (cCTRT) in locally advanced nasopharyngeal cancer (LANPC) | Journal of clinical oncology. ASCO Publications. https://ascopubs.org/doi/abs/10.1200/jco.2009.27.15_suppl.6046

Kim, T. H., Ko, Y. H., Lee, M. A., Kim, B., Chung, S. R., Yoo, I. R., Jung, C., Kim, Y., Kim, M. S., Sun, D., Hong, Y. S., Lee, K. S., & Kang, J. (2008). Treatment outcome of cisplatin-based concurrent Chemoradiotherapy in the patients with locally advanced Nasopharyngeal cancer. Cancer Research and Treatment, 40(2), 62. https://doi.org/10.4143/crt.2008.40.2.62

DOI: https://doi.org/10.32532/jori.v12i1.119 <