Efek Abscopal pada Kombinasi Radioterapi dan Imunoterapi

Agustinus Darmadi Hariyanto; Arie Munandar

doi:10.32532/jori.v11i1.105

Efek Abscopal pada Kombinasi Radioterapi dan Imunoterapi

Agustinus Darmadi Hariyanto, Arie Munandar

Sari

Radioterapi atau terapi radiasi merupakan salah satu prosedur medis lokal regional yang digunakan untuk menangani penyakit kanker. Bukti menunjukkan bahwa radiasi juga mampu memicu sistem imunitas tubuh dan hal ini berkontribusi pada efek abscopal, yang dapat didefinisikan sebagai "respons yang diperantarai oleh sistem imun pada jarak yang jauh dari volume atau target radiasi." Meskipun regresi tumor abscopal masih tetap merupakan peristiwa langka dalam praktik radioterapi, peningkatan jumlah kasus dilaporkan terutama sejak implementasi klinis agen imunoterapi. Beberapa hal terkait radiasi seperti regimen radiasi, biological equivalent dose/BED dan luas lapangan radiasi diketahui mampu memengaruhi efek abscopal

Kata Kunci

efek abscopal, imunoterapi, radioterapi

Teks Lengkap:

PDF

Referensi

Brix N, Tiefenthaller A, Anders H, Belka C, Lauber K. Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences. Vol. 280, Immunological Reviews. 2017. p. 249–79.

Dagoglu N, Karaman S, Caglar HB, Oral EN. Abscopal Effect of Radiotherapy in the Immunotherapy Era: Systematic Review of Reported Cases. Cureus. 2019;11(2).

Yilmaz MT, Elmali A, Yazici G. Abscopal Effect, From Myth to Reality: From Radiation Oncologists’ Perspective. Cureus. 2019;11(1):9–13.

Grass GD, Krishna N, Kim S. The immune mechanisms of abscopal effect in radiation therapy. Curr Probl Cancer [Internet]. 2015;1–15. Available from: http://dx.doi.org/10.1016/j.currproblcancer.2015.10.003

BS JL, Mackley HB. Combining immunotherapy with radiation therapy to induce the abscopal response: What clinical and treatment variables matter ? Appl Rad Oncol. 2019;8(1):14–9.

Buchwald ZS, Wynne J, Nasti TH, Zhu S, Mourad WF, Yan W, et al. Radiation, immune checkpoint blockade and the abscopal effect: A critical review on timing, dose and fractionation. Vol. 8, Frontiers in Oncology. 2018.

Golden EB, Apetoh L. Radiotherapy and Immunogenic Cell Death [Internet]. Vol. 25, Seminars in Radiation Oncology. Elsevier; 2015. p. 11–7. Available from: http://dx.doi.org/10.1016/j.semradonc.2014.07.005

Garg AD, Dudek-Peric AM, Romano E, Agostinis P. Immunogenic cell death. Int J Dev Biol. 2015;59(1–3):131–40.

Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol [Internet]. 2017;17(2):97–111. Available from: http://dx.doi.org/10.1038/nri.2016.107

Zhou J, Wang G, Chen Y, Wang H, Hua Y, Cai Z. Immunogenic cell death in cancer therapy: Present and emerging inducers. J Cell Mol Med. 2019;23(8):4854–65.

Ngwa W, Irabor OC, Schoenfeld JD, Hesser J, Demaria S, Formenti SC. Using immunotherapy to boost the abscopal effect [Internet]. Vol. 18, Nature Reviews Cancer. Nature Publishing Group; 2018. p. 313–22. Available from: http://dx.doi.org/10.1038/nrc.2018.6

Wani SQ, Dar IA, Khan T, Lone MM, Afroz F. Radiation Therapy and its Effects Beyond the Primary Target: An Abscopal Effect. Cureus. 2019;11(2):1–7.

Abuodeh Y, Venkat P, Kim S. Systematic review of case reports on the abscopal effect. Curr Probl Cancer [Internet]. 2016;40(1):25–37. Available from: http://dx.doi.org/10.1016/j.currproblcancer.2015.10.001

Marconi R, Strolin S, Bossi G, Strigari L. A meta-analysis of the abscopal effect in preclinical models: Is the biologically effective dose a relevant physical trigger? PLoS One. 2017;12(2):1–16.

Sekarutami SM, Handoko. The future of radiotherapy and immunotherapy concomitantly in cancer management. Med J Indones. 2019;28(4):391–5.

Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature [Internet]. 2015;520(7547):373–7. Available from: http://dx.doi.org/10.1038/nature14292

DOI: https://doi.org/10.32532/jori.v11i1.105 <